A Mathematical Review on Open Two Compartment Pharmacokinetic Models
Authors
Sunandan Dey
Abstract
This paper deals with the application of Laplace Transform to estimate the fate of a drug in the mammillary body with the prediction of various biological parameters (k, k12, and k21) through the method of residuals. The essential numerical values of k, k12, and k21 are estimated through the determination of the mathematical hybrid constants (A, B, a, b, and T). Besides, these values can predict the tissue concentration (ct) of the drug, and biological half-life (t1/2) as well. Thus, this study provides intuitive information on the fate of the administered drug in a mammillary body, successfully.
