Antibiotic Resistance in Oral Microbiota of Diabetic and Non-diabetic Populations in the Northern part of Bangladesh

Abstract: Oral infections are common and can be more serious in people with diabetes because their bodies do not fight infections well. Antibiotic resistance, where bacteria no longer respond to medicines, is becoming a big problem worldwide. In Bangladesh, there is little information about how oral bacteria in diabetic and non-diabetic patients resist antibiotics. This study will help understand these differences to improve treatment. Methods: A cross-sectional comparative study was conducted where initially 120 samples were distributed equally between diabetic and non-diabetic respondents and 10 gram positive and negative catalase samples were collected from the both group for this research. Results: It was found that the concentrations among antibiotics are significantly different for both groups. It was also noted that the bacterial inhibitions are different on the basis of different concentrations of antibiotics as well as the bacterial inhibitions are decreased as the concentrations of the antibiotics were decreased. Conclusion: The study emphasizes that diabetic patients require adjusted antibiotic regimens, often involving high er dosages, to effectively manage oral biofilm-associated infections. Azithromycin and gentamicin emerge as prom ising antibiotics due to their effectiveness at lower concentrations in this population. Tailoring antibiotic treatment strategies for diabetic individuals is crucial to improve clinical outcomes and combat oral infections effectively. Keywords: Antibiotic resistance, Diabetes mellitus, Periodontal disease, Oral biofilm, Periodontitis, Diabetic, Non-diabetic patients.